MAPKAP kinase 2-deficient mice are resistant to collagen-induced arthritis.

Resistant to Collagen-Induced Arthritis MAPKAP Kinase 2-Deficient Mice Are Nickerson-Nutter, Lih-Ling Lin and Jean-Baptiste Telliez

Cytosolic Phospholipase A2α–deficient Mice Are Resistant to Collagen-induced Arthritis

Pathogenic mechanisms relevant to rheumatoid arthritis occur in the mouse model of collagen-induced arthritis (CIA). Cytosolic phospholipase A2alpha (cPLA2alpha) releases arachidonic acid from cell membranes to initiate the production of prostaglandins and leukotrienes. These inflammatory mediators have been implicated in the development of CIA. To test the hypothesis that cPLA2alpha plays a ke...

IL-4 Can Inhibit IL-17 Production in Collagen Induced Arthritis

Background: IL-4 is a cytokine that induces differentiation of naive helper T cells into Th2 cells. Once activated by IL-4, Th2 cells subsequently produce additional IL-4. Objective: To examine the effect of IL-4 on IL-17 production and its effect in Collagen- Induced Arthritis (CIA) mice. Method: In this study, a chicken collagen-II-induced experimental arthritis (CIA) model was used in DBA/1 ...

Tyk2 deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice.

Tyrosine kinase-2 (Tyk2) participates in the signaling pathways of multiple cytokines in innate and acquired immunity. In the present study, we investigated the in vivo involvement of Tyk2 in anti-type II collagen antibody-induced arthritis (CAIA) using Tyk2-deficient mice. Hind paws of wild-type mice showed massive swelling and erythema by arthritogenic antibody injection, whereas Tyk2-deficie...

Cartilage oligomeric matrix protein deficiency promotes early onset and the chronic development of collagen-induced arthritis

INTRODUCTION Cartilage oligomeric matrix protein (COMP) is a homopentameric protein in cartilage. The development of arthritis, like collagen-induced arthritis (CIA), involves cartilage as a target tissue. We have investigated the development of CIA in COMP-deficient mice. METHODS COMP-deficient mice in the 129/Sv background were backcrossed for 10 generations against B10.Q mice, which are su...